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May 20 2015

Dental Research Seminar

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Date: May 27, 2015 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Ms. Basudan Aishah Mohammed A, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: ZONE-SPECIFIC GENE EXPRESSION OF MANDIBULAR CONDYLAR CARTILAGE: A Promising Approach or an Overcomplicated Strategy?

Abstract: Mandibular condylar cartilage (MCC) possesses a unique multizonal structure to perform its function as a lubricating and load-bearing surface in the TMJ and as a growth plate cartilage. Trauma and/or pathogenesis of the MCC, which has limited capacity for regeneration, are significant causes of morbidity in human beings. Thus, tissue engineering may provide an ideal solution, but current zone-specific information is limited to a small set of genes and proteins. Resolving functional and phenotypic differences between cell populations of the MCC is important to understand mechanisms of homeostasis and pathogenesis. In addition, the identification of zone specific differential gene expression is useful in tissue engineering approaches to recapitulate the native zonal architecture.

The aim of our study is to obtain new insights into the characterization of MCC cells by investigating gene expression profiles of individually isolated MCC zones. The question that arises: is this zonal-based investigation a promising approach or just an overcomplicated strategy?

Presenter: Miss Ren Chong, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: A randomized controlled trial of a laser-aided orthodontic treatment for patients with periodontitis

Abstract: The objective of this double-blind randomized controlled trial is to assess the effects of low-level laser therapy (LLLT) in orthodontic patients with periodontitis on pain, periodontal inflammation, alveolar bone remodeling and dentin sensitivity. Thirty-five nonsmoking patients (male or female, 18-60 years old) with controlled chronic periodontitis will be recruited. After insertion of the first archwire, one side of the arch will be randomly assigned to repeated LLLT (940nm, continuous mode and energy density: 3.57 J/cm2) and the other side to placebo laser. Following parameters will be recorded on selected time-points during the 12-month follow-up: visual analogue scale, bite force, cytokines in gingival crevicular fluid, bacteria levels in supragingival plaque, clinical parameters and cone-beam computed tomography. This study will provide first-hand evidence for the incorporation of LLLT in adjunctive orthodontic treatment for patients with chronic periodontitis.

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Apr 28 2015

Dental Research Seminar

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Date: May 5, 2015 (Tuesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Dr. Bhoj Manasi, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: A lab-centered approach for initiating early regeneration of dental pulp using specialized alginate biomimetic microenvironments.

Abstract: There is a significant need in modern endodontics to have living replacement for dental pulp that can salvage the infected necrotic tooth. The first step towards fabricating a dental pulp tissue is to construct a suitable cellular structural microenvironment. In this study we establish an environment by judicious selection of hDPSC and HUVEC encapsulated in RGD alginate infused with physiologically relevant quantities of VEGF and FGF. These environment constructs were fabricated in template of gutta percha shape mold. They were analyzed for viability, proliferation, morphological changes, distribution and growth factor release kinetics. Results from confocal and SEM showed uniform distribution of cells along the length of construct. They were viable with significant rate of proliferation, morphological changes and cell-clustering phenomena noted with formulation in constructs having one or both added growth factors than in growth factor-free constructs. The release kinetics showed significant results in groups with dual growth factors. We conclude that combining VEGF and FGF in 1:3 ratio to co-culture of DPSC-HUVEC could initiate denovo regeneration.

Presenter: Dr. Zakir Muhammad, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Bonding dissimilar materials in dentistry

Abstract: Bonding of dental restorative materials to tooth tissues is one of the most important aspects in dentistry. To meet the harsh oral environment coupling agents are used to enhance the adhesion between different materials. There has been considerable research on silane coupling agents compared to other coupling agents. Adhesion of metals and resin cements is the most important aspect for the longevity of the prosthesis. Titanium is used as a material of choice for dental implants and other metal dental prosthesis. Our aim is to use an optimized novel silane system and compare and contrast its adhesive properties to the commercially available surface modifiers and resin cements when titanium and resin cements are bonded. Different mechanical tests such as shear bond adhesion test, fractural analysis, scanning electron microscopy, atomic force microscopy (for surface roughness), energy dispersive X-ray spectroscopy are some tests which are going to be conducted. All the tests are going to be done after the specimens have been aged in water and after thermocycling. All the obtained data will be statistically analyzed and presented in the thesis and published studies.

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Apr 27 2015

Dental Research Seminar

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Date: April 30, 2015 (Thursday)
Time: 12:45 p.m. to 1:15 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Dr. Ab Malik Normaliza Binti, PhD Candidate

Title: Oral Health Promotion Intervention Among Stroke-Carers and Patients

Abstract: Disability caused by stroke can decrease patients’ quality of life through impacts on daily life activities. Rehabilitation services for patients with stroke are dedicated to improve the condition of patients and to support independence through education and training.  Oro-motor function and clearance are commonly perturbed following stroke, and daily toothbrushing is also impaired due to reduced manual dexterity.  Dental plaque accumulates at a faster rate, and opportunistic bacteria and yeast proliferate. While maintenance of oral health is a great challenge for patients after stroke, health care staff and caregivers are ideally positioned to support and assist these patients to maintain oral hygiene so as to prevent not only oral diseases but also life-threatening infections such as aspiration pneumonia.  Evaluations of oral care provided by caregivers and approaches for optimizing such care have received little attention.  Thus, this study aims to evaluate the factors that determine the oral health behavior of stroke care providers, and the impact of a tailored Computer-Assisted-Learning (CAL) programme.

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Apr 22 2015

Dental Research Seminar

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Date: April 28, 2015 (Tuesday) Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Miss Li Xin, PhD Candidate (12:45 p.m. to 1:15 p.m.)
Title: Bioimimetic Nature-Derived Antibacterial Surfaces for Modified Denture and Dental Restorative Materials

Abstract: Control of the oral microbiome under different disease, inflammatory and degenerative challenges is possible with antibiotics, anti-quorum sensing molecules and toxic heavy metals such as, silver nanoparticles. However, bacteria can quite rapidly evolve resistance to chemical agents. They cannot evolve mutations to counter physical structures that are able to damage and destroy them. Therefore, attention has focused on the use of micro- and nanostructures to kill pathogenic bacteria particularly derived from nature where self-cleaning surfaces are common.
In dentistry the ultimate aim is to develop strategies that affect species that have become virulently pathogenic and restore a normal interdependent balanced microbiome. Previously it has been reported that Cicada wing surfaces can selectively remove pathogenic, gram negative while maintaining non-pathogenic species. The post-like protrusions are effective in rupturing the membrane of thin-walled bacteria represented by the gram negative staining classification. We have studied a range of potential nature-derived candidates as templates for antibacterial surface structure. Gecko skin fulfils criteria for a superior antibacterial surface structure, because it consists of high aspect ratio nanohairs, confined in tight spacing and eliciting superhydrophobicity. Such intricate structures can be copied in any material allowing for their exploitation in biomedicine and dentistry.
The aim of this study is to measure the short-term bactericidal properties of gecko skin, and Epoxy resin polymer imprints and assess their feasibility to control two ubiquitous species of “surface associating” pathogenic oral bacteria with virulent biofilm forming potential. The goal is to confirm whether these surface structures can be usefully applied as bactericidal coatings at the surface of dental implants and restorations requiring bacterial control management.

 

Presenter: Dr. Govindool Sharaschandra Reddy, PhD Candidate (1:15 p.m. to 1:45 p.m.)
Title: Possibility of Key-Hole Revision of Endodontic Treatment

Abstract: The nonsurgical revision endodontic treatment may involve the perforation of intact crown, decementation of crown or crown and bridges and disobturation of radiographically satisfactory obturation, which may be unacceptable to the patient many a times. The option of surgical approach may not appeal to the patient or it may be too invasive in terms of the size of the persistent lesion or new lesion formed or just symptomatic tooth as described by the patient all of which have known to be of microbiological origin.
This research evaluates the possibility of an approach to a surgical technique, which is based on the concept of keyhole surgery in conjunction with photodynamic dye and laser activation to eradicate the extra-radicular infection in endodontically treated tooth and the periapical region. The feasibility is assessed in a series of experiments to evaluate the parameters that make this procedure a clinical possibility

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Apr 15 2015

Dental Research Seminar

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Date: April 22, 2015 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Dr. Du Yanlin, PhD Candidate

Title: Improving Oral Health for Children with Autism Spectrum Disorders

Abstract: Autism Spectrum Disorders (ASD) is a spectrum of developmental disorders characterized by impairments in communication and social skills. Maintaining good oral health requiring special care is a challenge because of multiple learning, communication and cogitative impairments. This has been the focus of my thesis with a theme of research relating to special care dentistry.

A systematic review of the oral health status of individuals with autism spectrum disorders was undertaken across five electronic databases employing PRISMA guidelines. The initial search yielded 727 papers, among which 36 were identified as potentially effective papers and 11 ‘effective’ case-control studies informed this review. Variations in oral health existed among children with and without ASD in terms of dental caries experience, periodontal health, malocclusion, dental injuries and bruxism. This has implication for special care practice and policies.

To understand ASD and oral health in the Hong Kong context a population-wide oral epidemiological study was undertaken among 17 randomly selected registered Special Child Care Centres. An age (±6 months) and gender matched sample of children from mainstreams preschools were recruited as the ‘control group’. Comprehensive oral health assessments were undertaken for over 500 children. Difference in clinical oral health status existed among preschool children with and without ASD in terms of dental caries experience (dmft>0), periodontal health (pp<0.001).

A clinical trial was undertaken to evaluate the effectiveness of a tooth-brushing visual pedagogy to improve oral health and enhance oral self-care among children with ASD in both intervention and control groups. Improvements in oral hygiene status and gingival health were observed over the 6-month period. Regression analyses identified the visual pedagogy intention was a significant factor associated with improved oral health (p This has implications for safeguarding and promoting good oral health among children with ASD in Hong Kong and beyond.

 

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Feb 05 2015

Dental Research Seminar

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Date: February 11, 2015 (Wednesday)

Time: 12:45 p.m. to 1:15 p.m.

Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Miss Yang Xinchen, PhD Candidate

Title: Multidimensional assessments on outreach dental services for older persons using long-term care services in Hong Kong

Abstract: Older persons using long-term care (LTC) services in Hong Kong are, in general, frail and suffering from various kinds of physical and/or mental impairment. Due to the frailty, a lower ability to take care of themselves and irregular dental checkup habit, the LTC users have unsatisfactory oral health status. Outreach dental service teams (ODT) program for the older persons is one of the major projects subsidized by the Hong Kong Government. This program targets at improving oral health of institutionalized older persons and older persons using day care centers/units through oral health education and provision of on-site dental treatments.

The aims of this study are to investigate the achievements and deficiencies of the ODT program from 3 dimensions: the recipients, the providers and the administrators of this outreach dental service.  Both quantitative and qualitative methods will be employed.

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Feb 04 2015

Dental Research Seminar

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Date: February 6, 2015 (Friday)

Time: 12:45 p.m. to 1:15 p.m.

Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Miss Yao Jie, PhD Candidate

Title: Development of an instrument to assess patients’ expectations of dental implant

Abstract: The public awareness of the benefits of dental implant therapy has increased recently. However, most patients are unaware of what the process details and information from Internet may cause unrealistic expectations that the treatment team cannot attain. Fulfilled expectations together with the actual treatment might be significant factors to patients’ satisfaction and good compliance. However, little is known that what patient’s expectation is on treatment with dental implant and how these expectations formed. An instrument to assess patients’ expectations of dental implants was developed based on Bowling’s Model of PEHC. Initial testing confirmed good-to-excellent face and content validity(CVI-clarity ratings ranged from 0.6 to 1.0 with a mean of 0.8. CVI-relevant ranged from 0.6 to 1.0 with a mean of 0.9). Further psychometric testing of the instrument (validity and reliability) is planned.

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Feb 02 2015

Dental Research Seminar

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Date: February 3, 2015 (Tuesday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lounge (Room 7A09), 7/F, The Prince Philip Dental Hospital

 

Presenter: Miss Yu Xiaolin, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Oral microbiota in periodontal/peri-implant niches

Abstract: Periodontitis is a progressive infectious-inflammatory disease that destroys the soft and hard tissues supporting the teeth. It is prevalent in global populations, leading to a significant healthcare burden. Initiation and progression of this disease are caused by a combination of various factors including the oral microbiota, host factors and external factors. Among these, a complex assortment of bacterial pathogens are regarded as the dominant causative factors. To date, dental implants and implant-supported restorations have become routine and essential treatments for partially or fully edentulous patients. However, biological complications; typically peri-implantitis and peri-implant mucositis have been reported after a period of functional loading. It is widely agreed that peri-implantitis and peri-implant mucositis are mainly associated with microbial plaque accumulation and bacterial infections, and present a high risk in subjects with a history of periodontitis. In my PhD studies, I will use next-generation sequencing approaches to investigate periodontal/peri-implant microbiota in subjects with both healthy and inflamed sites. Moreover, I will mainly focus on oral bacteria belonging to the Treponema and Synergistetes phyla. The complete genome sequences of selected poorly-chraracterized oral treponeme isolates will be analyzed to investigate taxonomy and phylogeny, and to identify pathogenic genes. As the vast majority of oral Synergistetes taxa are uncultivable, targeted single-gene clone-library approaches will be performed to investigate the diversity of genotypes and phylotypes present in subgingival plaque sampled from diseased and healthy sites.

 

Presenter: Miss Li Xuan, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Mesoporous silica nanoparticles-encapsulated TCMs inhibit oral pathogens and modulate inflammatory responses in human gingival epithelial cells

Abstract: Due to the porous structure and stable physical/chemical characteristics, mesoporous silica nanoparticles (MSNs) have emerged as a ‘hot’ biomedical agent that can be used as cell markers, imaging moieties, gene and drug vehicles. Meanwhile, several selected traditional Chinese medicines (TCMs) show potent anti-microbial and anti-inflammatory effects, such as Scutellariae Radix and green tea. Periodontitis results from plaque biofilms-induced uncontrolled immuno-inflammatory response that leads to substantial periodontal destruction and eventually teeth loss. Currently, two forms of MSNs (SR2 and M1) in different morphologies have been successfully synthesized, and their surfaces have been modified by amine and fluorescent dye. In the coming studies, the extracts ofScutellariae Radix and green tea would be loaded into the synthesized MSNs, and their loading efficiency and release profiles are tested. The anti-microbial effects via a prolong release manner on selected oral microbes are determined. The sub-localization of fluorescent SR2 and M1 in human gingival epithelial cells (HGECs) would be analyzed. Next, the potential anti-inflammatory effects of SR2 and M1-encapsulated TCMs are investigated in P. gingivalis and E. coli lipopolysaccharides(LPS)-treated HGECs. The underlying signaling mechanisms involved in the effects are explored by determining relevant profiles of genes and proteins.

 

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Jan 21 2015

Dental Research Seminar

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Date: January 29, 2015 (Thursday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Dr. Lee Hiu Man Gillian, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Clinical guideline for caries prevention and management by caries risk assessment for pre-school children in Hong Kong

 

Abstract: Dental treatment received by pre-school children with dental caries in Hong Kong is sub-optimal. Considerable variations in their care also exist among dental practitioners. Clinical practice guidelines assist decision making in clinical practice to produce optimal, evidence-based and equitable patient care. Traditional guideline development requires substantial amount of time, expertise and resources. A clinical practice guideline for caries prevention and management by caries risk assessment for pre-school children in Hong Kong was developed using ADAPTE process and internet-based Delphi consensus with the collaboration of the Hong Kong Society of Paediatric Dentistry. The systematic approach to develop this consensus evidence-based clinical guideline will be described. The guideline recommendations will also be presented.

 

Presenter: Mr. Jiang Shan, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Motivation interviewing in improving oral health of preschool children: a randomized controlled trial

 

Abstract: Dental caries (tooth decay) is highly prevalent and is largely attributable to unhealthy behaviors. Prevailing health education (HE) fails to achieve sustainable behavioral changes. This randomized controlled trial incorporates motivational interviewing (MI) and interactive caries risk assessment (RA) into HE and investigates the effectiveness of HE, HE+MI, and HE+MI+RA in changing oral health behaviors and preventing caries in preschool children. Six hundred and ninety-two (692) children with unfavorable oral health behaviors (insufficient toothbrushing and/or frequent snacking) were randomly assigned to 3 groups. Respective interventions were delivered to parents. Preliminary (6-month) findings showed significantly greater improvements in parental efficacy and children’s behaviors in HE+MI and HE+MI+RA groups, as compared with HE group.

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Jan 20 2015

Dental Research Seminar

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Date: January 28, 2015 (Wednesday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Miss Zhan Jingyu, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Use of sucrose substitutes in the prevention of dental caries

 

Abstract: The important role sucrose plays in the initiation and progression of dental caries has been shown in laboratory and human studies. A reasonable approach to prevent caries is to substitute sucrose in food and drinks with less cariogenic sweetening substances. At present, there are a number of sucrose substitutes in the market which are non- or low-cariogenic. Isomaltulose (alpha-D-glucopyranosyl-1, 6-fructose) is a natural sugar with a sweet taste which can provide energy and does not induce side effects, such as diarrhea, even when ingested in large quantity. It cannot be easily fermented by plaque bacteria and may be less cariogenic than sucrose. Findings of the series of laboratory studies we have conducted to investigate the cariogenicity of isomaltulose will be reported.

 

Presenter: Miss Wen Weiye, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Family-centered oral health promotion for new parents and their infants: a randomized controlled trial

 

Abstract: Early childhood caries (ECC) is a global health problem that causes pain and infection to the children affected. It is a common disease among preschool children in Hong Kong (31%-42% for 3-5 years old). ECC is found to be associated with a higher risk of dental caries in the primary and permanent dentitions and has negative effects on the nutrition, growth and development and general health of the children affected. We are now conducting a 4-year randomized controlled trial of family-centered oral health promotion for new parents aiming to increase the proportion of parents brushing their infants’ teeth, establishing proper feeding and dietary habits, reducing the transfer of MS (the main kind of cariogenic bacteria) from the parents to their infants and then reducing the risk of early childhood caries (ECC) at 3 years. We also aim to improve the oral hygiene status of the new parents and prevention of oral diseases among themselves.

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