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Feb 05 2015

Dental Research Seminar

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Date: February 11, 2015 (Wednesday)

Time: 12:45 p.m. to 1:15 p.m.

Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Miss Yang Xinchen, PhD Candidate

Title: Multidimensional assessments on outreach dental services for older persons using long-term care services in Hong Kong

Abstract: Older persons using long-term care (LTC) services in Hong Kong are, in general, frail and suffering from various kinds of physical and/or mental impairment. Due to the frailty, a lower ability to take care of themselves and irregular dental checkup habit, the LTC users have unsatisfactory oral health status. Outreach dental service teams (ODT) program for the older persons is one of the major projects subsidized by the Hong Kong Government. This program targets at improving oral health of institutionalized older persons and older persons using day care centers/units through oral health education and provision of on-site dental treatments.

The aims of this study are to investigate the achievements and deficiencies of the ODT program from 3 dimensions: the recipients, the providers and the administrators of this outreach dental service.  Both quantitative and qualitative methods will be employed.

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Feb 04 2015

Dental Research Seminar

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Date: February 6, 2015 (Friday)

Time: 12:45 p.m. to 1:15 p.m.

Venue: The Lounge, 7/F, The Prince Philip Dental Hospital

Presenter: Miss Yao Jie, PhD Candidate

Title: Development of an instrument to assess patients’ expectations of dental implant

Abstract: The public awareness of the benefits of dental implant therapy has increased recently. However, most patients are unaware of what the process details and information from Internet may cause unrealistic expectations that the treatment team cannot attain. Fulfilled expectations together with the actual treatment might be significant factors to patients’ satisfaction and good compliance. However, little is known that what patient’s expectation is on treatment with dental implant and how these expectations formed. An instrument to assess patients’ expectations of dental implants was developed based on Bowling’s Model of PEHC. Initial testing confirmed good-to-excellent face and content validity(CVI-clarity ratings ranged from 0.6 to 1.0 with a mean of 0.8. CVI-relevant ranged from 0.6 to 1.0 with a mean of 0.9). Further psychometric testing of the instrument (validity and reliability) is planned.

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Feb 02 2015

Dental Research Seminar

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Date: February 3, 2015 (Tuesday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lounge (Room 7A09), 7/F, The Prince Philip Dental Hospital

 

Presenter: Miss Yu Xiaolin, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Oral microbiota in periodontal/peri-implant niches

Abstract: Periodontitis is a progressive infectious-inflammatory disease that destroys the soft and hard tissues supporting the teeth. It is prevalent in global populations, leading to a significant healthcare burden. Initiation and progression of this disease are caused by a combination of various factors including the oral microbiota, host factors and external factors. Among these, a complex assortment of bacterial pathogens are regarded as the dominant causative factors. To date, dental implants and implant-supported restorations have become routine and essential treatments for partially or fully edentulous patients. However, biological complications; typically peri-implantitis and peri-implant mucositis have been reported after a period of functional loading. It is widely agreed that peri-implantitis and peri-implant mucositis are mainly associated with microbial plaque accumulation and bacterial infections, and present a high risk in subjects with a history of periodontitis. In my PhD studies, I will use next-generation sequencing approaches to investigate periodontal/peri-implant microbiota in subjects with both healthy and inflamed sites. Moreover, I will mainly focus on oral bacteria belonging to the Treponema and Synergistetes phyla. The complete genome sequences of selected poorly-chraracterized oral treponeme isolates will be analyzed to investigate taxonomy and phylogeny, and to identify pathogenic genes. As the vast majority of oral Synergistetes taxa are uncultivable, targeted single-gene clone-library approaches will be performed to investigate the diversity of genotypes and phylotypes present in subgingival plaque sampled from diseased and healthy sites.

 

Presenter: Miss Li Xuan, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Mesoporous silica nanoparticles-encapsulated TCMs inhibit oral pathogens and modulate inflammatory responses in human gingival epithelial cells

Abstract: Due to the porous structure and stable physical/chemical characteristics, mesoporous silica nanoparticles (MSNs) have emerged as a ‘hot’ biomedical agent that can be used as cell markers, imaging moieties, gene and drug vehicles. Meanwhile, several selected traditional Chinese medicines (TCMs) show potent anti-microbial and anti-inflammatory effects, such as Scutellariae Radix and green tea. Periodontitis results from plaque biofilms-induced uncontrolled immuno-inflammatory response that leads to substantial periodontal destruction and eventually teeth loss. Currently, two forms of MSNs (SR2 and M1) in different morphologies have been successfully synthesized, and their surfaces have been modified by amine and fluorescent dye. In the coming studies, the extracts ofScutellariae Radix and green tea would be loaded into the synthesized MSNs, and their loading efficiency and release profiles are tested. The anti-microbial effects via a prolong release manner on selected oral microbes are determined. The sub-localization of fluorescent SR2 and M1 in human gingival epithelial cells (HGECs) would be analyzed. Next, the potential anti-inflammatory effects of SR2 and M1-encapsulated TCMs are investigated in P. gingivalis and E. coli lipopolysaccharides(LPS)-treated HGECs. The underlying signaling mechanisms involved in the effects are explored by determining relevant profiles of genes and proteins.

 

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Jan 21 2015

Dental Research Seminar

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Date: January 29, 2015 (Thursday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Dr. Lee Hiu Man Gillian, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Clinical guideline for caries prevention and management by caries risk assessment for pre-school children in Hong Kong

 

Abstract: Dental treatment received by pre-school children with dental caries in Hong Kong is sub-optimal. Considerable variations in their care also exist among dental practitioners. Clinical practice guidelines assist decision making in clinical practice to produce optimal, evidence-based and equitable patient care. Traditional guideline development requires substantial amount of time, expertise and resources. A clinical practice guideline for caries prevention and management by caries risk assessment for pre-school children in Hong Kong was developed using ADAPTE process and internet-based Delphi consensus with the collaboration of the Hong Kong Society of Paediatric Dentistry. The systematic approach to develop this consensus evidence-based clinical guideline will be described. The guideline recommendations will also be presented.

 

Presenter: Mr. Jiang Shan, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Motivation interviewing in improving oral health of preschool children: a randomized controlled trial

 

Abstract: Dental caries (tooth decay) is highly prevalent and is largely attributable to unhealthy behaviors. Prevailing health education (HE) fails to achieve sustainable behavioral changes. This randomized controlled trial incorporates motivational interviewing (MI) and interactive caries risk assessment (RA) into HE and investigates the effectiveness of HE, HE+MI, and HE+MI+RA in changing oral health behaviors and preventing caries in preschool children. Six hundred and ninety-two (692) children with unfavorable oral health behaviors (insufficient toothbrushing and/or frequent snacking) were randomly assigned to 3 groups. Respective interventions were delivered to parents. Preliminary (6-month) findings showed significantly greater improvements in parental efficacy and children’s behaviors in HE+MI and HE+MI+RA groups, as compared with HE group.

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Jan 20 2015

Dental Research Seminar

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Date: January 28, 2015 (Wednesday)

Time: 12:45 p.m. to 1:45 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Miss Zhan Jingyu, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Use of sucrose substitutes in the prevention of dental caries

 

Abstract: The important role sucrose plays in the initiation and progression of dental caries has been shown in laboratory and human studies. A reasonable approach to prevent caries is to substitute sucrose in food and drinks with less cariogenic sweetening substances. At present, there are a number of sucrose substitutes in the market which are non- or low-cariogenic. Isomaltulose (alpha-D-glucopyranosyl-1, 6-fructose) is a natural sugar with a sweet taste which can provide energy and does not induce side effects, such as diarrhea, even when ingested in large quantity. It cannot be easily fermented by plaque bacteria and may be less cariogenic than sucrose. Findings of the series of laboratory studies we have conducted to investigate the cariogenicity of isomaltulose will be reported.

 

Presenter: Miss Wen Weiye, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Family-centered oral health promotion for new parents and their infants: a randomized controlled trial

 

Abstract: Early childhood caries (ECC) is a global health problem that causes pain and infection to the children affected. It is a common disease among preschool children in Hong Kong (31%-42% for 3-5 years old). ECC is found to be associated with a higher risk of dental caries in the primary and permanent dentitions and has negative effects on the nutrition, growth and development and general health of the children affected. We are now conducting a 4-year randomized controlled trial of family-centered oral health promotion for new parents aiming to increase the proportion of parents brushing their infants’ teeth, establishing proper feeding and dietary habits, reducing the transfer of MS (the main kind of cariogenic bacteria) from the parents to their infants and then reducing the risk of early childhood caries (ECC) at 3 years. We also aim to improve the oral hygiene status of the new parents and prevention of oral diseases among themselves.

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Dec 31 2014

Dental Research Seminar

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Date: January 8, 2015 (Thursday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Dr. Daood Umer, PhD Candidate

 

Title: The effect of quaternary ammonium salts (QAS) on bacterial biofilms and resin-dentin adhesives: invitro and spectroscopic studies

 

Abstract: Incomplete removal of caries-infected dentine during cavity preparation may result in secondary caries formation and entrapment of bacteria within the cavity. The quaternary ammonium compound, 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (SiQAC), is commonly used as antimicrobial coatings of medical devices and garment fabrics mainly due to its long, lipophilic C18 alkyl chain that penetrates bacterial cell membrane and causes cell death. More recently, SiQAC has been coupled to other trialkoxysilanes with methacryloxy or epoxy functionalities via sol-gel platform chemistry that utilises tetrethoxysilane or dimethyldiethoxysilane as the anchoring unit.

 

This study evaluated the effect of different concentrations of QAS (quaternary ammonium silanes)-containing cavity disinfectants on bond strength and nanoleakage of ethanol and acetone based adhesives; alongwith Raman spectra of evaluation of dentin substrates with multispecies biofilms grown and treated. The study was also classified to verify the susceptibility profile of different bacterial strains to QAS disin­fectants. The use of 20% QAS cavity disinfectants improved dentine bond strength and interfacial Nanoleakage with Raman micro spectroscopy showing significant effect of QAS compounds against multispecies biofilms resulted in 80% elimination of bacterial strains.

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Dec 22 2014

Dental Research Seminar

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Date: December 29, 2014 (Monday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Yuan Changyong, MPhil Candidate

Title: EphrinB2 enhances angiogenesis and anastomosis of bioengineered prevascularized dental pulp construct

Abstract:
Aims: To reveal the role of ephrinB2 in angiogenesis during coculture of stem cells from apical papilla (SCAP) and human umbilical vein endothelial cells (HUVEC); and lead to enhance anastomoses between prevascularised dental pulp construct and host vasculature.

Methods: EphrinB2 gene expression in SCAP and HUVEC will be modified by transfection and RNA interference (RNAi). Modified SCAP and HUVEC will be cocultured in biomimetic extracellular matrix, and the number and the average length of sprouts will be examined. The phosphorylation of ephrinB2 and EphB4 in SCAP cocultured with HUVEC will be detected using western blot. Prevascularized SCAP/EphrinB2 and HUVEC will be seeded into root canal, and implanted into immunodeficient mice at the same time, SCAP/vector and HUVEC only will be used as control. Implants will be harvested at days-1,-2,-3,-5,-7 and the formation of new blood vessel will be detected using immunohistochemical technique.

Expected Results: 1. EphrinB2 plays a critical role in SCAP enrolment as pericyte-like cells and facilitate assembly with endothelial cells. 2. Overexpression of ephrinB2 in SCAP and HUVEC in pulp tissue regeneration will accelerate the formation of capillary networks.

Conclusion: EphrinB2 may play an important role in angiogenesis and in vivo anastomosis, and could be a new target molecule for improving angiogenesis during regenerative endodontic therapy.

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Dec 16 2014

Dental Research Seminar

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Date: December 23, 2014 (Tuesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Zhang Jiaguan, MPhil Candidate

Title: A randomized clinical trial on the effect of a chlorine dioxide spray on dental plaque and respiratory pathogens in institutionalized elders

Abstract: Long term care institutions face a formidable challenge with the projected increase in the population of dependent elders in the coming decades. Poorer oral health has been consistently observed amongst institutionalized elders compared to community-dwelling elders, and this has been attributed to a number of factors including compromised physical and mental capabilities, resulting in a general loss of functional independence. This is further compounded by a general lack of awareness and neglect of oral hygiene by nursing home staff, whom residents depend on for the majority of their daily selfcare. Absence of daily oral hygiene results in the build-up of dental plaque and allows the uninhibited growth of opportunistic bacteria, which have been shown to cause lower respiratory tract infections such as aspiration pneumonia, one of the most common infectious causes of death among institutionalized elders. While there is a general consensus that an antimicrobial agent should be used as part of an optimal daily oral hygiene regimen in institutionalized elders, agreement has yet be reached regarding the optimal agent and its method of application. Delivery of an antimicrobial agent as a mouthwash may be problematic for frail elders who may be mentally impaired and unable to follow instructions, or have swallowing impairments and at a risk for aspiration. The use of an oral spray has been shown to be effective in other patient groups, and may be more appropriate and applicable for institutionalized elders. While chlorhexidine serves as the gold standard for anti-plaque effectiveness, prolonged usage is contraindicated due to side effects which include tooth staining and calculus formation. Chlorine dioxide is an effective antimicrobial agent, and short term studies have suggested a comparable anti-plaque activity compared to chlorhexidine, as well as the absence of these side effects. We  now propose to test the effectiveness of a chlorine dioxide spray against a chlorhexidine spray in the reduction of dental plaque, oral respiratory pathogens, and incidence of aspiration pneumonia amongst institutionalized elders. All participants will be expected to benefit from the administered interventions, and we hope to develop an optimal oral hygiene protocol which can easily be adopted at a low cost by nursing homes regionally in Hong Kong, and potentially worldwide.

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Nov 10 2014

Dental Research Seminar

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Date: November 17, 2014 (Monday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Ms. Li Lingwei, PhD Candidate

Title: A longitudinal study of obesity and dental caries among Hong Kong adolescents

Abstract: Obesity greatly impacts adolescents’ physical and psychological health. Obesity and dental caries are thought to share a common pathogenesis in nutrition, parenting, lifestyle, physical, social environment, as well as psychosocial factors. Studies have been conducted among various countries to investigate the relationship between adiposity and tooth decay. However, most of these studies were performed in a cross-sectional setting and indicated conflicting findings. The aim of this study is to investigate the relationship between obesity and dental caries among Hong Kong adolescents over time. In this seminar, a systematic review will be presented to highlight the current research status. The methodology of the present study will also be introduced.

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Oct 08 2014

Dental Research Seminar

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Date: October 15, 2014 (Wednesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Wu Zhaoming, MPhil Candidate

Title:The role of TRAF-interacting protein (TRAIP) during craniofacial development

Abstract: The control of cell proliferation is crucial for the craniofacial development. But the mechanism of how the cell proliferation is coordinated during the development remains to be elucidated. The TRAF-interacting protein (TRAIP) is an E3 ubiquitin ligase, which plays a role in cell proliferation and differentiation. It has also found been to interact with the cell cycle related protein PCNA. In this study the expression pattern of TRAIP during different stages of craniofacial development will be investigated and its potential relationship with cell proliferation will be evaluated. Its potential upstream and downstream signals will also be explored.

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