Apr 17 2013
Date: April 26, 2013 (Friday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital
Presenter: Miss Sununliganon Laddawun, PhD Candidate
Title: Stem cell approach for maxillary sinus grafting in atrophic maxilla
Maxillary sinus grafting is required in atrophic maxilla to facilitate dental implant placement. Autogenous bone is a standard grafting material but bone harvesting procedure is traumatic to patients. Bone substitute is used as an alternative but bone formation is limited. Mesenchymal stem/stomal cells (MSC) supplement to promote bone regeneration was introduced to provide a cellular-based tissue engineering method.
This study aimed to evaluate the bone regeneration capacity of bone marrow aspirate concentrate (BMAC) in maxillary sinus grafting. Quantitative and qualitative analysis of bone marrow aspirate was performed before and after concentration. Animal study in rabbits’ maxillary sinus was carried out to compare 4 grafting materials. A pilot human study was also conducted. The results showed that bone marrow aspirate can be concentrated by a one-step centrifuge method with confirmation of the presence of MSCs having differentiation capabilities. In addition, BMAC transplantation is a worthy therapeutic option for bone grafting.