May 20 2015
Date: May 27, 2015 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital
Presenter: Ms. Basudan Aishah Mohammed A, PhD Candidate (12:45 p.m. to 1:15 p.m.)
Title: ZONE-SPECIFIC GENE EXPRESSION OF MANDIBULAR CONDYLAR CARTILAGE: A Promising Approach or an Overcomplicated Strategy?
Abstract: Mandibular condylar cartilage (MCC) possesses a unique multizonal structure to perform its function as a lubricating and load-bearing surface in the TMJ and as a growth plate cartilage. Trauma and/or pathogenesis of the MCC, which has limited capacity for regeneration, are significant causes of morbidity in human beings. Thus, tissue engineering may provide an ideal solution, but current zone-specific information is limited to a small set of genes and proteins. Resolving functional and phenotypic differences between cell populations of the MCC is important to understand mechanisms of homeostasis and pathogenesis. In addition, the identification of zone specific differential gene expression is useful in tissue engineering approaches to recapitulate the native zonal architecture.
The aim of our study is to obtain new insights into the characterization of MCC cells by investigating gene expression profiles of individually isolated MCC zones. The question that arises: is this zonal-based investigation a promising approach or just an overcomplicated strategy?
Presenter: Miss Ren Chong, PhD Candidate (1:15 p.m. to 1:45 p.m.)
Title: A randomized controlled trial of a laser-aided orthodontic treatment for patients with periodontitis
Abstract: The objective of this double-blind randomized controlled trial is to assess the effects of low-level laser therapy (LLLT) in orthodontic patients with periodontitis on pain, periodontal inflammation, alveolar bone remodeling and dentin sensitivity. Thirty-five nonsmoking patients (male or female, 18-60 years old) with controlled chronic periodontitis will be recruited. After insertion of the first archwire, one side of the arch will be randomly assigned to repeated LLLT (940nm, continuous mode and energy density: 3.57 J/cm2) and the other side to placebo laser. Following parameters will be recorded on selected time-points during the 12-month follow-up: visual analogue scale, bite force, cytokines in gingival crevicular fluid, bacteria levels in supragingival plaque, clinical parameters and cone-beam computed tomography. This study will provide first-hand evidence for the incorporation of LLLT in adjunctive orthodontic treatment for patients with chronic periodontitis.
Comments Off on Dental Research Seminar| 62 views