Apr 22 2015
Date: April 28, 2015 (Tuesday) Time: 12:45 p.m. to 1:45 p.m.
Venue: The Lounge, 7/F, The Prince Philip Dental Hospital
Presenter: Miss Li Xin, PhD Candidate (12:45 p.m. to 1:15 p.m.)
Title: Bioimimetic Nature-Derived Antibacterial Surfaces for Modified Denture and Dental Restorative Materials
Abstract: Control of the oral microbiome under different disease, inflammatory and degenerative challenges is possible with antibiotics, anti-quorum sensing molecules and toxic heavy metals such as, silver nanoparticles. However, bacteria can quite rapidly evolve resistance to chemical agents. They cannot evolve mutations to counter physical structures that are able to damage and destroy them. Therefore, attention has focused on the use of micro- and nanostructures to kill pathogenic bacteria particularly derived from nature where self-cleaning surfaces are common.
In dentistry the ultimate aim is to develop strategies that affect species that have become virulently pathogenic and restore a normal interdependent balanced microbiome. Previously it has been reported that Cicada wing surfaces can selectively remove pathogenic, gram negative while maintaining non-pathogenic species. The post-like protrusions are effective in rupturing the membrane of thin-walled bacteria represented by the gram negative staining classification. We have studied a range of potential nature-derived candidates as templates for antibacterial surface structure. Gecko skin fulfils criteria for a superior antibacterial surface structure, because it consists of high aspect ratio nanohairs, confined in tight spacing and eliciting superhydrophobicity. Such intricate structures can be copied in any material allowing for their exploitation in biomedicine and dentistry.
The aim of this study is to measure the short-term bactericidal properties of gecko skin, and Epoxy resin polymer imprints and assess their feasibility to control two ubiquitous species of “surface associating” pathogenic oral bacteria with virulent biofilm forming potential. The goal is to confirm whether these surface structures can be usefully applied as bactericidal coatings at the surface of dental implants and restorations requiring bacterial control management.
Presenter: Dr. Govindool Sharaschandra Reddy, PhD Candidate (1:15 p.m. to 1:45 p.m.)
Title: Possibility of Key-Hole Revision of Endodontic Treatment
Abstract: The nonsurgical revision endodontic treatment may involve the perforation of intact crown, decementation of crown or crown and bridges and disobturation of radiographically satisfactory obturation, which may be unacceptable to the patient many a times. The option of surgical approach may not appeal to the patient or it may be too invasive in terms of the size of the persistent lesion or new lesion formed or just symptomatic tooth as described by the patient all of which have known to be of microbiological origin.
This research evaluates the possibility of an approach to a surgical technique, which is based on the concept of keyhole surgery in conjunction with photodynamic dye and laser activation to eradicate the extra-radicular infection in endodontically treated tooth and the periapical region. The feasibility is assessed in a series of experiments to evaluate the parameters that make this procedure a clinical possibility
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